In medieval English, the word took on the meaning of a flatterer, sycophant or parasite - someone out to please others with artifice rather than substance.
Then in the early nineteenth century, this meaning of the word started to be used by physicians. A medical dictionary published in 1811 defined a placebo as
"an epithet given to any medicine adapted more to please than benefit the patient".
[From reading Daniel Moerman's "Meaning, Medicine and the 'Placebo Effect'"]
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